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Biologic Manufacturing Process Training
Module 3.3 - Downstream - Virus Inactivation Process

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Home └Biologic Manufacturing Process Training └Module 3.3 - Downstream - Virus Inactivation Process

Biologic Manufacturing Process Training

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Module 1 - Biological products and pharmaceutical drugs
- Module 1 - Biological products and pharmaceutical drugs 10 xp
  - Quiz
Module 2 - Upstream Process
Module 3 - Downstream Process
Module 4 - Central Services
- Module 4.1 - Central Service - Media Preparation 10 xp
  - Quiz
- Module 4.2 - Central Service - Buffer Preparation 10 xp
  - Quiz

Module 3.3 - Downstream - Virus Inactivation Process

10 XP

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1. What is one unique feature of retroviruses regarding their replication process?

They replicate exclusively in animal cells They contain both double-stranded DNA and single-stranded RNA Their RNA genome is reverse transcribed into DNA They infect only specific types of cells

2. Which technique is commonly employed for viral removal in biologic downstream processing?

Protein A affinity chromatography Cation exchange chromatography (CEX) Reverse transcription Nanofiltration systems

3. Which principle primarily enables the removal of viruses in Planova Virus Reduction filtration?

Affinity binding Size exclusion Ion exchange Hydrophobic interaction

4. What distinguishes endogenous viruses from non-endogenous viruses in biologic manufacturing?

Endogenous viruses originate from external sources. Non-endogenous viruses are integrated into the host cell genome. Endogenous viruses contaminate Master Cell Banks (MCBs) Non-endogenous viruses are inherent to the cell lines used for protein expression.

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